Local Drug Delivery Systems in the Treatment of Aggressive Periodontitis: a Pilot Study

Objective: The present study was designed to evaluate the clinical effects of topical application of CHLO-SITE (Chlorhexidine gel) in management of aggressive periodontitis. Material and Methods: This study was carried out on 5 patients (aged 25-50) with aggressive periodontitis. They were received scaling and root planning (SRP) alone in one side and SRP plus CHLO-SITE (Chlorhexidine gel) in other side. Each individual was subjected to the following measurements; (1) Evaluation of the clinical parameters pre and post treatment to detect the outcome of the treatment modality, or at1, 3, 6, months were obtained for microbiological evaluation. Results: Results showed that (1) CHLO-SITE (Chlorhexidine gel) delivered locally into periodontal disease sites reduced all subgingival bacteria and (2) Both treatment and modality led to a highly statistically significant reduction in microbiological counts as well as clinical parameters applied. No clinical relevant side effects were observed.